Kaempferol May Become The Next New Star in Plant Extract Field

Kaempferol is a flavonoid-type polyphenol. It can be found in many foods for human consumption, including Brussels sprouts, tea leaves, grapefruit, cauliflower, apples, onions, red wine, and some berries, among others. This compound has been found to have many positive effects on human health. Studies have shown that it helps prevent heart disease and cancer.

Different flavonols can have positive effects on human health, including compounds such as quercetin and myricetin. Kaempferol is thought to be especially helpful in reducing the risk of fatal heart disease in women.

Kaempferol, the most common flavonoid, has been associated with a reduced risk of cancer with long-term meals. Studies have reported that high intake of kaempferol can reduce the recurrence of advanced colorectal adenomas, and, compared with other daily dietary flavonoids, high intake of kaempferol also significantly reduces the risk of pancreatic cancer. Recent studies have shown that kaempferol can also inhibit hepatocyte growth factor (HGF) and its receptor tyrosine protein kinase, which are related to the growth and metastasis of childhood medulloblastoma, so dietary kaempferol can be used to prevent and treat this disease. a disease.

Studies have shown that kaempferol has good antibacterial activity and also has an effect on methicillin-resistant Staphylococcus aureus (MRSA). The K-Br disc method shows that the concentration of 50 mg/tablet can make the inhibition zone of MRSA reach 8.5 mm, which also has good antibacterial activity against Vibrio cholerae and Enterococcus faecalis. In terms of antiviral, kaempferol exhibited concentration-dependent inhibition at non-cytotoxic concentrations.

In terms of anti-inflammatory, kaempferol mainly achieves anti-inflammatory effect by inhibiting the expression of inflammatory factors.

Atherosclerosis (AS) is a chronic inflammatory disease of the blood vessel wall. Studies have shown that kaempferol can not only inhibit copper ion-induced oxidation of low-density lipoprotein (LDL) to oxidized low-density lipoprotein (ox-LDL), It can also reduce the expression of CD36 protein on the surface of THP-1 macrophages and prevent the uptake of ox-LDL by the cells, thereby preventing the occurrence of atherosclerosis.

Diabetes is an endocrine and metabolic disease that seriously threatens human health, and its incidence is increasing at an unprecedented rate. Studies have shown that kaempferol has the effect of acting as an agonist with the hypoglycemic drug rosiglitazone, but its adverse effects are far weaker than those of rosiglitazone. Intake, it indicates that it is expected to become a new generation of insulin sensitizers.